THE IMPORTANCE OF LABORATORY RESULTS IN THE TREATMENT OF LIVER DISEASE
Abstract
Chronic liver disease is a progressive deterioration of liver functions. Liver functions include the production of clotting factors and other proteins, detoxification of harmful products of metabolism, and excretion of bile. This is a continuous process of inflammation, destruction, and regeneration of liver parenchyma leading to fibrosis and cirrhosis. Cirrhosis is a final stage of chronic liver disease that results in disruption of liver architecture, the formation of widespread nodules, vascular reorganization, neo-angiogenesis, and deposition of an extracellular matrix. The underlying mechanism of fibrosis and cirrhosis at a cellular level is the recruitment of stellate cells and fibroblasts that cause fibrosis, while parenchymal regeneration relies on hepatic stem cells.
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