BLEEDING IN THE ARID ZONE OF CENTRAL ASIA ON THE EXAMPLE OF THE KHOREZM REGION

Abstract

For a clinician, in light of the latest achievements in hepatology, the most significant is probably the possibility of a differentiated etiological approach to the diagnosis and treatment of liver diseases. And this, despite the fact that in a variety of etiological processes, the liver can be the only or main target, causing significant uniformity of the main pathological reactions. In this sense, the old saying "Qui bene diagnostit, bene curat" retains its meaning and can only be supplemented in our time "Qui bene et tempore diagnostit, bene curat" - "He who diagnoses well and in a timely manner, treats well." It is well known that liver cirrhosis is a stage of hepatopathy. Its purely pathological definition is quite definite: reorganization of the entire liver structure due to the development of fibrosis and nodular regeneration (D. Alagille, 1982). The lobular structure, as well as the vascular system, is disorganized; over time, this reorganization leads to portal hypertension. Most liver diseases can lead to the development of cirrhosis. Among them, viral diseases, such as viral hepatitis, predominate in the Central Asian region. According to literature (Loginov A.S., 1987), cirrhosis of viral etiology is the outcome of chronic active hepatitis of viral etiology, which accounts for 50-55% of all patients with chronic hepatitis. Much less often, it is the outcome of chronic persistent hepatitis. Slowly evolving through the stages of chronic disease, the pathological process in the liver within five years ends with the formation of cirrhosis in 0.8-1.0% of patients who have had symptomatic or anicteric form of viral hepatitis type A or B. In rare cases, cirrhosis develops immediately after acute viral hepatitis, bypassing the stage of chronic hepatitis.